Accession Number:

ADA455127

Title:

Mechanism of Tissue Remodeling in Sepsis-Induced Acute Lung Injury

Descriptive Note:

Final rept. 18 Mar 2002-17 Mar 2006

Corporate Author:

ATLANTA RESEARCH AND EDUCATION FOUNDATION DECATUR GA

Personal Author(s):

Report Date:

2006-04-01

Pagination or Media Count:

12.0

Abstract:

Acute lung injury ALI is a major cause of morbidity and mortality in the U.S., and sepsis is a common cause. We have found that chronic ethanol abuse renders the host susceptible to ALI. This project explores the mechanisms by which ethanol affects the lung focusing on lung fibroblasts. Specifically, it uses in vitro and in vivo models to evaluate the mechanisms of lung tissue remodeling in the setting of chronic ethanol exposure and sepsis.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE