Accession Number:

ADA455088

Title:

Genetic and Hormonal Risk Factors for Cancer in African American Men

Descriptive Note:

Annual rept. 1 May 2005-30 Apr 2006

Corporate Author:

MICHIGAN UNIV ANN ARBOR

Personal Author(s):

• Sarma, Aruna

Report Date:

2006-05-01

Pagination or Media Count:

31.0

Abstract:

African American men are at greater risk for developing and dying from prostate cancer compared to white men. This disparity is likely due to a number of factors including environmental and genetic factors. The Flint Men s Health Study FMHS was established in 1995 as a population-based case-control study of African American men aged 40-79 residing in Genesee County, Michigan. The initial sample consisted of 730 men who completed an in-home interview consisting of potential risk factors for prostate cancer medical history and demographic data. 431 men provided a blood sample and 369 men who were determined to be free of cancer completed a comprehensive urologic exam. Additionally, 119 cases of prostate cancer have been identified from the same population. Studies have suggested a role for hormones and genetics in cancer incidence. However, studies have been completed in white populations and results have been conflicting. The objective of this study is to more clearly delineate the potential roles of selected hormones and growth factors in prostate cancer development.

Descriptors:

• *HORMONES
• *GENETICS
• *AFRICAN AMERICANS
• *PROSTATE CANCER
• RISK
• POPULATION
• ANDROGENS
• POLYMORPHISM
• MALES
• MEDICAL RESEARCH

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE