Identification, Characterization, and Clinical Development of the New Generation of Breast Cancer Susceptibility Alleles
Annual rept. 1 Mar 2005-28 Feb 2006
ROYAL CANCER HOSPITAL LONDON (UNITED KINGDOM) INST OF CANCER RESEARCH
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Breast cancer is a common disease in women but the causes are still largely unknown. There is considerable evidence to suggest that genetic factors play an important role in causing breast cancer, but the genes involved in the majority of breast cancers are currently unknown. Our aim is to identify genetic factors that increase the chance of breast cancer occurring. We have collected clinical information and samples from over 1500 breast cancer families. We will compare the frequency of genetic factors in these cases with control women without breast cancer. Initially we will analyze genes that we suspect may have a role in breast cancer. However over the course of the study we plan to use new technologies to analyze every gene 30,000 genetic variants. If we find any variants that are more frequent in breast cancer cases than controls, it suggests that they may be involved in causing breast cancer. We will evaluate these variants in further cases and controls to prove an association with breast cancer and to define the risk and outcomes of carrying the genetic variants.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research