Genetic Epidemiology of Prostate Cancer
Annual rept. 1 Jun 2005-28 Feb 2006
CALIFORNIA UNIV IRVINE
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Prostate cancer results from complex interactions among genetic, endocrine, and environmental factors. Understanding genetic risk factors that contribute to the occurrence of prostate cancer is crucial to design both preventative and therapeutic strategies and to identify at-risk individuals. This knowledge could reduce the incidence of and death from this disease. The primary objective of this grant is to investigate changes in genes that directly and indirectly regulate levels of male hormones, which in turn, affect prostate cell growth, and may ultimately cause cancer. In this past 8 months, we have genotyped the DNA samples for eight haplotype-tagging SNPs in IGF1, an additional ten SNPs in IGF1R,one additional SNP in IRS1 and three additional SNPs in IGFBP3, as well as performed genotyping of the SRD5A2 V89L and CYP3A4 B1 polymorphisms from the original proposal. We have performed statistical analysis of the 18 IGF1R SNPs and the PI3KCB and SHC1 SNPs. Two of the IGF1R SNPs were significantly associated with Gleason score. More analyses are in progress.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research