Accession Number:

ADA454849

Title:

Non-Invasive Monitoring for Optimization of Therapeutic Drug Delivery by Biodegradable Fiber to Prostate Tumor

Descriptive Note:

Annual rept. 21 Jan 2005-20 Jan 2006

Corporate Author:

TEXAS UNIV AT ARLINGTON

Personal Author(s):

Report Date:

2006-02-01

Pagination or Media Count:

15.0

Abstract:

Chemotherapeutic Drugs delivered by systematic administration exhibit great toxicity patients have to endure suffering from frequent injection or low dose IV treatment. Thus controlled release of these drugs will be a treatment modality. Moreover, realtime monitoring of the effects of the drug by sensing the dynamic response of the tumor to a particular drug can significantly enhance the therapeutic outcome. The Hypotheses are 1 A near-infrared NIR imager can non-invasively monitor the dynamic and chronic distribution of the chemotherapeutic drug, vascular oxygenation, and blood volumes in prostate tumors. 2 The dynamic response of prostate tumor oxygenation to the chronic drug delivery can serve as indicator for treatment prognosis. The Specific Aims are 1 To design and implement a NIR spectroscopic imaging system 2 To develop 2D tomographic imaging of drug concentration and tumor oxygenation. 3 to control the delivery of drug and 4 to study the relationship between drug release rate, tumor oxygen levels and therapeutic outcome.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE