Accession Number:
ADA454849
Title:
Non-Invasive Monitoring for Optimization of Therapeutic Drug Delivery by Biodegradable Fiber to Prostate Tumor
Descriptive Note:
Annual rept. 21 Jan 2005-20 Jan 2006
Corporate Author:
TEXAS UNIV AT ARLINGTON
Personal Author(s):
Report Date:
2006-02-01
Pagination or Media Count:
15.0
Abstract:
Chemotherapeutic Drugs delivered by systematic administration exhibit great toxicity patients have to endure suffering from frequent injection or low dose IV treatment. Thus controlled release of these drugs will be a treatment modality. Moreover, realtime monitoring of the effects of the drug by sensing the dynamic response of the tumor to a particular drug can significantly enhance the therapeutic outcome. The Hypotheses are 1 A near-infrared NIR imager can non-invasively monitor the dynamic and chronic distribution of the chemotherapeutic drug, vascular oxygenation, and blood volumes in prostate tumors. 2 The dynamic response of prostate tumor oxygenation to the chronic drug delivery can serve as indicator for treatment prognosis. The Specific Aims are 1 To design and implement a NIR spectroscopic imaging system 2 To develop 2D tomographic imaging of drug concentration and tumor oxygenation. 3 to control the delivery of drug and 4 to study the relationship between drug release rate, tumor oxygen levels and therapeutic outcome.
Descriptors:
- *FIBERS
- *MONITORING
- *DRUGS
- *PROSTATE CANCER
- *BIODETERIORATION
- *CHEMOTHERAPY
- VOLUME
- DELIVERY
- REAL TIME
- DISTRIBUTION
- DYNAMIC RESPONSE
- NEOPLASMS
- IMAGES
- CHEMOTHERAPEUTIC AGENTS
- PROSTATE GLAND
- BLOOD VOLUME
- CONCENTRATION(CHEMISTRY)
- CARDIOVASCULAR SYSTEM
- HYPOTHESES
- THERAPY
- RELEASE
- DOSAGE
- OXYGEN
- RATES
- TOXICITY
- SPECTROSCOPY
- OPTIMIZATION
- DETECTION
- PREDICTIONS
Subject Categories:
- Biochemistry
- Medicine and Medical Research
- Pharmacology