Accession Number:

ADA454441

Title:

Well-Posedness Results for a Class of Toxicokinetic Models

Descriptive Note:

Corporate Author:

NORTH CAROLINA STATE UNIV AT RALEIGH CENTER FOR RESEARCH IN SCIENTIFIC COMPUTATION

Personal Author(s):

Report Date:

2001-07-24

Pagination or Media Count:

30.0

Abstract:

sThis paper addresses theoretical issues related to a class of nonlinear parabolic systems used in toxicokinetic modeling. We establish the well-posedness of these systems in a weak or variatioaal setting by proving the existance of a unique solution which depends continuously oa the data. These results are then applied specifically to tbe model equatious for a physiologically based pharmacokinetic model for tbe systemic transport of trichloroethylene TCE, which is the motivating example for our efforts here.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE