Evaluation of the Effects of Multiple Immunizations Administered in a Stressful Environment on Immunologic Function
Annual rept. 1 Mar 2005-28 Feb 2006
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
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It is hypothesized that multiple vaccinations administered simultaneously in a stressful environment may induce an exaggerated Th2 immune response and adverse health effects. Epidemiological surveys have preliminarily confirmed adverse health effects but not Th2 immune responses in multiply immunized war veterans. We propose a prospective clinical trial in a military recruit population 6 5 0to test the hypothesis that multiple, simultaneous vaccinations in a stressful environment induce an exaggerated Th2 immune response in addition to adverse Th2- associated symptoms. This study aims to compare the immune responses and health effects in recruits undergoing a multiple, simultaneous vaccination schedule with the s a l e variables in those immunized with a staggered schedule. A Marine recruit population with routine high levels of stress will be split into I multiple, simultaneous and 2 staggered vaccination groups. Cytokine and lymphocyte levels in addition to lymphocyte stimulation studies will be performed on blood samples to compare immune responses. Questionnaires, sick call databases, and comprehensive electronic military health databases will be used to compare health outcomes. Immunity to infectious pathogens is critical for maintaining military readiness, but the potential effects of multiple, simultaneous vaccinations are not well known. This study will contribute to existing research on the possible impact of multiple vaccinations administered under stressful conditions.
- Medicine and Medical Research