Accession Number:

ADA454054

Title:

Physiologic and Endocrine Correlates of Overweight and Obesity in African Americans and Caucasians

Descriptive Note:

Annual rept. 1 Mar 2005-28 Feb 2006

Corporate Author:

HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD

Personal Author(s):

Report Date:

2006-03-01

Pagination or Media Count:

9.0

Abstract:

Obesity has reached epidemic levels and yet the incidence continues to rise. The current study is seeking to examine the hypothesis that obesity may reflect dysfunctioning of the hypothalamic-pituitary-adrenal H PA axis in response to stressors. African American persons are at greatest risk, but reasons for this difference are unknown. We will study 120 men and women of Caucasian and African American ethnicity and examine their responses to physiologic stressors exercise and ingestion of a meal. Methods The HPA axis will be studied in some detail by using two stressor paradigms and two steroid regimens. We expect to be able to detect subtle differences in HPA axis reactivity in obese individuals that might contribute to morbidity and perhaps even make individuals resistant to therapeutic interventions. Results We have enrolled 96 participants, with 66 completed. Data collection and analyses are proceeding on schedule. Two abstracts were submitted and accepted for presentation in Spring 2006. Conclusions We are on schedule for all study milestones and look forward to being able to answer the important questions regarding the potential role of the HPA axis in obesity.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE