Accession Number:

ADA453847

Title:

Detection of Leukocyte Activation in Pigs With Neurologic Decompression Sickness

Descriptive Note:

Corporate Author:

NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD

Report Date:

2004-01-01

Pagination or Media Count:

5.0

Abstract:

In a porcine model of neurological decompression sickness DCS, perivascular leukocyte activation was a consistent finding in biopsies of associated cutaneous DCS. This prompted examination of other organs for similar changes multifocal leukocyte activation was found in the lungs pneumonitis and liver hepatitis. Hypothesis DCS in pigs induces leukocyte aggregation and activation in the liver and lungs. Methods Male Yorkshire swine, trained to run on a modified treadmill, were compressed to 200 ft of seawater fsw in a dry, air-filled compression chamber. Decompression varied according to the profile under study. Results In 106 pigs, evidence for association of leukocyte aggregation and activation with the clinical diagnosis of neurologic DCS was sought. The incidence of pneumonitis 2068, 29 with DCS 438, 10 without DCS and hepatitis 2368, 33 with DCS 438, 10 without DCS were strongly correlated with the incidence of neurologic DCS via Pearson Chi-squared analysis p 0.026 pneumonitis and p 0.008 hepatitis.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE