Accession Number:

ADA453576

Title:

Data Mining Algorithms with Pseudoknot Free Codes

Descriptive Note:

Final rept. Jan 2005-Jan 2006

Corporate Author:

MACULA (ANTHONY J) GENESSEO NY

Personal Author(s):

Report Date:

2006-05-01

Pagination or Media Count:

22.0

Abstract:

Synthetic DNA is proposed for use as an information storage media and three-dimensional structural material in nanotechnology. The main requirement of these systems is large collections of oligonucleotides that will not crosshybridize. The process of designing them has come to be known as DNA word, or DNA code, design. In this research, the DNA code generating software, SysDCode was developed and refined to include pseudoknot secondary structure, simulate hybridization assays, and applied to DNA hybridization algorithms. SynDCode has the ability to create new DNA codes with high binding specificity, filter existing codes through verification, and extend codes where specific oligonucleotides are essential to overall system construction. SynDCodes robust yet efficient computational model allows for the exploration of unparalleled search space spawning superior codes with higher binding specificity.

Subject Categories:

  • Biochemistry
  • Polymer Chemistry
  • Computer Programming and Software

Distribution Statement:

APPROVED FOR PUBLIC RELEASE