Accession Number:

ADA453351

Title:

Erbium: YAG Laser Incision of Urethral Structures for Treatment of Urinary Incontinence After Prostate Cancer Spray

Descriptive Note:

Final rept. 1 Feb 2003-31 Jan 2006

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

2006-02-01

Pagination or Media Count:

57.0

Abstract:

Urethral strictures and bladder neck contractures occur in 5-20 of prostate cancer surgeries, causing incontinence. Conventional stricture treatments have widely variable success rates with sub-optimal results. Treatment failure is presumably due to mechanical andor thermal damage to the urethra during the procedure. The objective of this research project was to test a novel ErbiumYAG laser for precise incision of the urethral stricture with minimal damage to adjacent healthy tissue. We hypothesized that minimal side-effects caused during Erbium laser incision should translate into limited scarring and improved procedural success rates. Year1 of this project was devoted to optimization of the laser and optical fiber delivery system for rapid and precise cutting of urethral tissue, ex vivo. We accomplished these tasks, and published our findings in the form of four manuscripts and two abstracts. Year 2 was devoted to in vivo animal studies comparing the wound healing after Erbium and Holmium laser incision of the urethra and bladder neck. Further improvement of the optical fiber delivery system was also accomplished. We published our findings in the form of five manuscripts and two abstracts. Year 3 was devoted to preparing for clinical studies and obtaining further funding for commercialization of the fiber optic delivery system. One manuscript was published and one is in review.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE