Detoxification of Chemical Warfare Agents by the Plant Cholinergic System
WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD
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Plants have cholinesterases pChEs, anti-ChEs, and activators of ChEs. We have isolated pChE from mung bean sprout. We investigated 300 plants and found that 75 of them contained anti- ChE that inhibited ChEs. Thirty-five percent contained activators of ChEs. An activator of ChE from wheat leaf, Tritiacche-T123 , activates fetal bovine serum AChE, equine BChE, and pChE. This non-oxime natural plant product may offer a new approach to the reactivation of OP-inhibited ChEs. pChE showed substrate differences from human acetylcholinesterase AChE or butyrylcholinesterase, hydrolyzing propionylthiocholine acetylthiocholine butyrylthiocholine. pChEs might also be useful as bioscavengers of OP nerve agents.
- Genetic Engineering and Molecular Biology
- Chemical, Biological and Radiological Warfare