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Promoter Switching and Transcription Factor Usage During Breast Adipocyte Differentiation: Role in Aromatase Expression and Activity
Final rept. 1 Sep 2003-31 Aug 2005
KANSAS CITY GENERAL HOSPITAL MO HARRY S TRUMAN MEDICAL RESEARCH LABS
Pagination or Media Count:
A murine cell-culture 3T3-Ll model of fibroblast-to-adipocyte differentiation was validated and used to demonstrate aromatase gene promoter-switching. Validation of a human cell culture model used in definitive further studies is nearly complete. The pace of progress was initially affected adversely by the loss of a technician who departed in February 2004 to relocate out of state with her family. Efforts to find a suitably qualified replacement were unsuccessful until late in October 2004. The new technician engaged to start work on November 29, 2004 was expected to greatly facilitate completion of workproposed under Specific Aim 1, and Aims 2 and 3 corresponding to Tasks 1, 2 and 3, respectively during the ensuing no-cost extension period. However, this technician had to be removed from the grant by the end of June 2005, for persistent substandard performance in execution and completion of essential proect tasks. Despite significant personnel setbacks cited above, completion of ongoing work is projected for later in the last quarter of 2005.
APPROVED FOR PUBLIC RELEASE