Molecular Characterization of Prostate Cancer Cell Oncolysis by Herpes Simplex Virus ICP0 Mutants
Annual rept. 15 Sep 2004-14 Sep 2005
MCMASTER UNIV HAMILTON (ONTARIO)
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This report outlines the progress made on our Exploration Hypothesis Development Award within the past 12 months. Briefly, the goals of the proposal were to characterize the oncolytic capacity of Herpes simplex virus type 1 ICPO mutants in prostate cancer cells given the relationship between ICPO and two tumor suppressors, RNase L and PML, implicated in prostate cancer progression. Here, we report that ICPO prevents an RNase L-independent rRNA degradation event in infected cells appended manuscript. We also provide preliminary evidence that suggests that the ability of ICP0-null HSV-1 mutants to selectively kill prostate cancer cells correlates with a reduction in PML levels. Furthermore, we briefly discuss experiments to be completed within the remaining six months of this award.
- Anatomy and Physiology
- Medicine and Medical Research