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Image-Guided Surgery of Primary Breast Cancer Using Ultrasound Phased Arrays

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Final rept. 1 Jul 2001-30 Jun 2005

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Recent developments of piezocomposite transducer technology have led to the development of new generation of ultrasound phased arrays with imaging and therapeutic capabilities. These dual-mode arrays provide an ideal nonionizing noninvasive tool for the treatment of primary breast cancer. This project investigates the thresholds for tissue damage under a variety of exposure conditions to high-intensity focused ultrasound from dual-mode arrays. In addition, we investigate new imaging techniques for enhanced visualization of thermal lesions in tissue media. These investigations are carried on ex-vivo animal tissue and in-vitro breast tissue and will lead to the design of a new generation of phased array drivers capable of supporting both the imaging and therapeutic requirements of the dual-mode system. We have characterized the therapeutic and imaging capabilities of a 64-element array prototype in a variety of tissues and under a range of normal exposure and over-exposure conditions. In conjunction with this experimental study, we have developed the simulation code for prediction of tissue damage based on the transient bioheat equation BHTE. We have also designed and implemented a prototype data collection system that serves as the basis of a real-time system for image-guided therapy.

Subject Categories:

  • Medicine and Medical Research
  • Computer Programming and Software
  • Acoustics

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