Accession Number:

ADA446908

Title:

Physico-Chemical Prokaryote Models: Stand-Alone Modules and Karyote Integration

Descriptive Note:

Final technical rept. Sep 2002-Sep 2005

Corporate Author:

INDIANA UNIV AT BLOOMINGTON THEORETICAL CHEMISTRY LAB

Personal Author(s):

Report Date:

2006-03-01

Pagination or Media Count:

35.0

Abstract:

At the Center for Cell and Virus Theory CCVT several types of systems biology modules were developed for the Bio- SPICE project. The cell modeling modules account for metabolic, proteomic and genomic kinetics and their spatially localized, multiple scale character. Modules for model development, calibration and multiplex e.g. genome-wide expression data interpretation are also provided. Models are made available via three complementary mechanisms 1 the Bio-SPICE system 2 open source stand-alone code and 3 a website sysbio.indiana.edu run by CCVT. The latter can also be run through the Bio-SPICE Dashboard. CCVT software has been demonstrated in a variety of contexts including transcriptional regulatory networks in prokaryotes and B cells, self-organized division mechanisms in E. coli, glycolysis in yeast and T. brucei, and the transcriptional response of human cells subjected to toxins. As CCVT also has an educational function, a number of graduate and undergraduate students have been trained as the next generation of systems biologists.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE