Acute Lung Injury Following Smoke Inhalation: Predictive Value of Sputum Biomarkers and Time Course of Lung Inflammation
Annual rept., 15 Apr 2004-14 Apr 2005
ARIZONA UNIV TUCSON
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BACKGROUND The role of lung inflammatory mediators in the development of lung injury following smoke inhalation is unknown. OBJECTIVE To evaluate the predictive value and role of inflammatory mediators in acute lung injury following smoke inhalation. SPECIFIC AIMS 1 Determine the predictive value of initial inflammatory markers in bronchial secretions of smoke inhalation victims for subsequent lung injury. 2 Measure longitudinal changes in inflammatory mediators in smoke inhalation victims. STUDY DESIGN Bronchial secretions from 200-250 intubated patients with smoke inhalation injury will be evaluated for initial and longitudinal changes, concentrations of substance P, TNF-alpha, IL-1, IL-8, and IL-10, as well as cell count and differential, every two hours to a maximum of 72 hours. Initial lung inflammation and changes in inflammatory markers will be compared in patients with and without subsequent significant lung injury. PROGRESS TO DATE We have enrolled 25 subjects to date in the study, almost all of whom have developed acute lung injury. We have collected detailed clinical outcome data on these subjects and have started to analyze substance P, TNF-alpha, IL-1, IL-8, and IL-10 concentrations. Determination of the concentrations, predictive of the severity of subsequent lung injury, await the recruitment and analysis of additional subjects.
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