The Effect of Total Sleep Deprivation and Recovery Sleep on Cognitive on Performance and Brain Function
Annual rept. 15 Jul 2004-15 Jul 2005
VETERANS MEDICAL RESEARCH FOUNDATION SAN DIEGO CA
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An ever-increasing number of military personnel and civilians alike must work daily without adequate sleep. Although considerable data show that sleep deprivation alters many aspects of behavior, little is known about changes in the brain substrate underlying the behavioral effects, and even less is known about the cerebral effects of recovery sleep. The overarching objective of this study is to investigate the effects of 2 full nights of sleep loss 66 hours total and 2 full nights of recovery sleep on cognitive performance and brain function. We will study 40 individuals for 6 nights and 6 days. Over the course of this period, subjects will receive 4 polysomnograms and 10 functional magnetic resonance imaging FMRI sessions. During the FMRI sessions, functional brain imaging data will be collected while subjects perform each of 3 cognitive tasks. These data will provide a rich amount of information concerning the effects of prolonged total sleep deprivation and recovery sleep on cognitive performance and the cerebral underpinnings of that performance. Preliminary analyses n30 are revealing the course of deterioration and recovery in cognitive performance and the specific component processes of cognition affected by sleep deprivation. We have also initially reported distinct patterns of recovery for different sleep parameters after sleep deprivation, and the possibility of using the FMRI measures to identify neural correlates of vulnerability and resilience to sleep deprivation.
- Medicine and Medical Research
- Stress Physiology
- Numerical Mathematics