Beta-Catenin: A Potential Survival Marker of Breast Cancer Stem Cells
Annual summary rept. 1 Sep 2004-31 Aug 2005
BAYLOR COLL OF MEDICINE HOUSTON TX
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The Wntbeta-catenin pathway has been extensively studied for its role in development and cancer. It has been established that Wntbeta-catenin signaling regulates the self renewal of normal stem cells in the hematopoietic system, the epidermis, as well as many other organs, but the importance of this pathway in breast stemprogenitors has not yet been investigated. The overall objective of this study is to determine the mechanisms by which beta-catenin might promote breast stemprogenitor cell survival, while inhibiting mammary differentiation. If the Wntbeta-catenin signal transduction pathway is critical for breast stem cell survival, it may be possible to sensitize these cells to chemotherapeutic agents by inhibiting this pathway. These studies may, therefore, provide new targets for understanding the etiology of, and be critical for the design of new treatments for, breast cancer.
- Anatomy and Physiology
- Medicine and Medical Research