Intervention Study of Flaxseed in Postmenopausal Women: Effects on Hormonal Biomarkers of Breast Cancer Risk
Final rept. 1 Jul 2002-30 Dec 2005
MASSACHUSETTS UNIV AMHERST
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The objective of this study is to determine if flaxseed supplementation to usual diet in postmenopausal women had a beneficial effect on important hormonal biomarkers of breast cancer risk. Participants received 6 weeks of usual diet plus 7.5 grams per day of raw flaxseed, followed by 6 weeks of usual diet plus 15 grams per day of raw flaxseed. Serum and urinary levels of hormonal biomarkers of breast cancer risk were assessed at baseline, 7 weeks and 13 weeks. There were small declines in serum levels testosterone, estrone and estradiol after six and 12 weeks of flaxseed ingestion among all women n47 but these were not statistically significant. Among overweightobese women body mass index 25kgm2 n23, there were more substantial declines in serum levels of testosterone, estrone and estradiol associated with consumption of a flaxseed diet. Serum levels of sex hormone binding globulin were essentially unchanged in normal and overweightobese women. Additional analyses are underway to evaluate changes in urinary hormone metabolites associated with flaxseed intake.
- Medicine and Medical Research