The Effect of Hypotensive Resuscitation and Fluid Type on Mortality, Bleeding, Coagulation, & Dysfunctional Inflammation in a Swine Grade V Liver Injury Model
OREGON HEALTH SCIENCES UNIV PORTLAND
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Exsanguination is the leading cause of death on the battlefield. Lifesaving interventions include arresting hemorrhage and initiating resuscitation. The ideal resuscitation of combat casualties has not been determined. Delaying resuscitation has been shown to be beneficial in some settings and anesthetics utilized can have a profound effect on the resuscitation. The goal of this proposal is to determine the ideal resuscitation regimen of swine undergoing a Grade V liver injury followed by 30 minutes of uncontrolled hemorrhagic shock. Fluids studied include lactated Ringers LR, normal saline NS and various concentrations of hypertonic saline. Fluids were evaluated based on their effects on mortality, metabolic changes, blood pressure, tissue oxygenation and inflammatory changes measured in the lung. The effect of total intravenous anesthesia TIVA on the model was also studied.
- Anatomy and Physiology
- Medicine and Medical Research