Effects of Moderate Aerobic Exercise Combined With Caloric Restriction on Circulating Estrogens and IGF-1 in Premenopausal Women
Annual summary rept. 17 Sep 2001-16 Sep 2005
PENNSYLVANIA STATE UNIV UNIVERSITY PARK
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This proposal entitled Effects of moderate aerobic exercise combined with caloric restriction on circulating estrogens and IGF-1 in premenopausal women examined the effects of exercise training combined with caloric restriction, resulting in weight loss, on two hormonal biomarkers for breast cancer i.e., circulating estrogens and insulin-like growth factor I IGF-I. In 33 women who completed the study, exercise 4 X per wk at 79 -6 of maximal heart rate combined with an 32 decrease in caloric intake over four menstrual cycles produced significant increases in aerobic capacity 27-5, decreases in body weight loss ranging from 1-9 kg, and loss of body fat ranging from 5 to 12 of initial percent fat. Light conditioning resulted in significant gains in aerobic capacity 30-5, but only produced a trend toward a decrease in body fat percent -1.2, and only a small change in body weight -0.8 kg. Despite the highly significant changes in body composition and body weight in the exercising group, preliminary results indicate no significant changes in serum estradiol or serum estrone. IGF-I did not change significantly either, indicating that chronic exercise and dieting do not result in favorable changes in two hormonal biomarkers for breast cancer.
- Medicine and Medical Research