Develpment of a Microfluidic Device for the Study of Breast Cancer Cell Migration
Annual summary rept. 1 Sep 2004-31 Aug 2005
CALIFORNIA UNIV IRVINE
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This project focuses on the development of microfluidic chambers for the study of breast cancer cell chemotaxis. We are continuing our work on characterizing breast cancer cell chemotaxis in epidermal growth factor EGF gradients. We developed a parallel gradient microfluidic chemotaxis chamber, allowing different gradients to be generated side by side. Using this chamber, we compared the effects of different EGF gradients on breast cancer cell chemotaxis, and observed subtle different in the migratory response. We also characterized the effect of an EGFR antagonist on chemotaxis. As we move forward in this project, we will continue to investigate breast cancer cell chemotaxis in different gradient conditions and different chemoattractants.
- Anatomy and Physiology