BRCC36, A Novel Subunit of a BRCA1/2 E3 Ubiquitin Ligase Complex: Candidate Breast Cancer Susceptibility Gene
Final rept. 1 Sep 2003-31 Aug 2005
FOX CHASE CANCER CENTER PHILADELPHIA PA
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liBesides family history of cancer and an individuals age, no single etiologic factor can identify women at an increased risk for the disease. Approximately 10 of all cases of breast cancer exhibit a familial pattern of incidence. Efforts to identify the genetic basis of familial breast cancer reached fruition some years ago, when the breast-cancer susceptibility genes, BRCA1 and BRCA2 were identified. However, recent studies have suggested that mutations in these genes are associated with a smaller number 20 to 60 of hereditary breast cancer families than originally estimated, especially in studies that have been based on population-based family materials. Several groups including ours are searching for additional breast cancer susceptibility genes using whole genome scanning approaches, but the success of many of these approaches depend on the underlying heterogeneity of the remaining cancer susceptibility loci. The failure to date to identify additional breast cancer susceptibility genes associated with the high risk of disease suggests that more than one may exist. We have taken the approach that the next BRCA genes will be those that encode for proteins whose functions are linked to important cell regulatory pathways. We have recently found one such candidate BRCA3 protein, referred to as BRCC36.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research