Accession Number:

ADA446657

Title:

Comprehensive Systematic Surveillance for Adverse Effects of Anthrax Vaccine Adsorbed, US Armed Forces, 1998-2000

Descriptive Note:

Journal article

Corporate Author:

ARMY CENTER FOR HEALTH PROMOTION AND PREVENTIVE MEDICINE WASHINGTON DC ARMY MEDICAL SURVEILLANCE ACTIVITY

Report Date:

2002-11-06

Pagination or Media Count:

10.0

Abstract:

Routine vaccinations of US military personnel with Anthrax Vaccine Adsorbed began in 1998. To systematically identify clinical diagnoses reported more frequently after vaccination than before, all military personnel were retrospectively assigned to pre- or post-vaccination cohorts. Cohort assignments were based on vaccination statuses each day of the 3-year surveillance period. For each cohort, rates of hospitalizations and ambulatory visits for 843 specific diagnoses were calculated using data in a public health surveillance system. Compared to the pre-vaccination cohort, the post-vaccination cohort had statistically higher rates of hospitalizations for 17 diagnoses, of ambulatory visits for 34 diagnoses, and in both clinical settings for one diagnosis malaria. After accounting for systematic differences in codingreporting and residual confounding, the number and nature of clinical diagnoses more frequent after anthrax vaccination than before were consistent with expectations due to random variation. This surveillance suggests that Anthrax Vaccine Adsorbed has few, if any, clinically significant adverse effects.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology
  • Military Forces and Organizations

Distribution Statement:

APPROVED FOR PUBLIC RELEASE