The Role of RAs in Myc-Induced Mammary Tumorigenesis
Annual summary rept. 1 May 2004-30 Apr 2005
PENNSYLVANIA UNIV PHILADELPHIA
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We have previously demonstrated that induced MYC oncogene expression in the murine mammary epithelium results in the formation of mammary tumors. MYC-induced tumors known to have Kras2 mutations all fail to regress after MYC deinduction while most tumors without the mutations do regress. We have attempted to build a second transgenic mouse model to regulate Kras2 expression independently of MYC in the mammary gland. After testing and characterizing the transgenic mice from this system, we have concluded that this system cannot be successfully used to regulate Kras2 in the mammary gland. As an alternative method, we are currently attempting to retrovirally infect MYC-induced tumors cells with virus expressing active Kras2.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research