Mechanism of Tissue Remodeling in Sepsis-Induced Acute Lung Injury
Annual rept. 18 Mar 2004-17 Mar 2005
ATLANTA RESEARCH AND EDUCATION FOUNDATION DECATUR GA
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Acute lung injury ALI is a major cause of morbidity and mortality in the U.S., and sepsis is a common cause. We have found that chronic ethanol abuse renders the host susceptible to ALI. This project explores the mechanisms by which ethanol affects the lung focusing on lung fibroblasts. Specifically, it uses in vitro and in vivo models to evaluate the mechanisms of lung tissue remodeling in the setting of chronic ethanol exposure and sepsis.
- Medicine and Medical Research
- Stress Physiology