Chemoprevention of Ovarian Cancer
Annual rept. 1 Oct 2004-30 Sep 2005
M D ANDERSON CANCER CENTER HOUSTON TX
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The overarching hypothesis of this project is that 4-HPR a synthetic vitamin A and oral contraceptives OCP induce apoptosis, possibly through induction of TGFbeta production by stromal cells, as well as by direct interaction with the surface epithelial cells, and these two cell types may act synergistically. In Project 1, 18 adult Rhesus monkeys were given 4-HPR, OCP, the combination, or no medication for 3 months. There were consistent differences in the absolute fluorescence intensities and relative contributions noted between pre- and post-drug measurements in each drug group. A second study involving 30 Cynomolgus macaques and using a crossover design has been completed immunohistochemical analysis of several biomarkers and analysis of the fluorescence spectroscopy data are ongoing. Project 2 has been transferred to the University of Arizona with the relocation of Dr. Molly Brewer. One patient has completed the study on the OCP arm, and 4 other patients are in line to start on the study pending approval of their surgery. In Project 3, the author have focused on understanding the mechanism of action of 4-HPR in tissue culture using both normal and immortalized epithelial cells. Studies are now complete.
- Medicine and Medical Research