Effects of Nicotine Administration and Stress on Sensory-Gating Depend on Rat Strain and Sex
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF MEDICAL AND CLINICAL PSYCHOLOGY
Pagination or Media Count:
The present experiments investigated the effects of nicotine administration, nicotine cessation, and stress environmental and physical on the acoustic startle reflex ASR and pre-pulse inhibition PPI of the ASR measures of sensory-gating in males and females of two rat strains. Experiment 1 examined the effects of nicotine on 192 Long-Evans rats a non-albino strain in individual or crowded housing. For males, nicotine increased ASR and PPI in the crowded condition, but decreased these responses in the individually housed condition. For females, nicotine reduced ASR and PPI regardless of housing condition. Experiment 2 examined the effects of nicotine 0, 6, or 12 mgkgday and immobilization IM stress on ASR and PPI of male and female Long-Evans and Sprague-Dawley albino rats N240. Nicotine decreased ASR and PPI responses of Long-Evans subjects. Nicotine enhanced Sprague-Dawley subjects responses. Stress increased responses of Sprague-Dawley males and Long-Evans females but decreased responses of Sprague-Dawley females and Long-Evans males.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Stress Physiology