Accession Number:

ADA446482

Title:

Fibroblast Growth Factor Receptor-4 and Prostate Cancer Progression

Descriptive Note:

Annual rept. 15 Sep 2004-14 Sep 2005

Corporate Author:

BAYLOR COLL OF MEDICINE HOUSTON TX

Personal Author(s):

Report Date:

2005-10-01

Pagination or Media Count:

9.0

Abstract:

We have found that the FGFR-4 Arg388 allele is strongly associated with the occurrence of prostate cancer and with metastasis and PSA recurrence in men undergoing radical prostatectomy. We will test the role of FGFR-4 in prostate cancer metastasis using autochthonous and orthotopic mouse models of cancer. We will also identify changes in gene expression due to the presence of the FGFR-4 Arg388 allele that lead to the metastatic phenotype. To this end we have established and carried out the initial characterization of trangenic mice with prostatic specific expression of FGFR-4 Arg388 and Gly388 constructed a FGFR-4 siRNA lentivirus and a PC3 siRNA cell line and identified Ehm2 as an FGFR-4 Arg388 regulated gene and characterized its role in prostate cancer. These key reagents will allow us to evaluate the effects of FGFR-4 on prostate cancer progression in vivo. Further studies of FGFR-4 Arg388 regulated gene expression in prostate cancer tissues are underway.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE