Fibroblast Growth Factor Receptor-4 and Prostate Cancer Progression
Annual rept. 15 Sep 2004-14 Sep 2005
BAYLOR COLL OF MEDICINE HOUSTON TX
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We have found that the FGFR-4 Arg388 allele is strongly associated with the occurrence of prostate cancer and with metastasis and PSA recurrence in men undergoing radical prostatectomy. We will test the role of FGFR-4 in prostate cancer metastasis using autochthonous and orthotopic mouse models of cancer. We will also identify changes in gene expression due to the presence of the FGFR-4 Arg388 allele that lead to the metastatic phenotype. To this end we have established and carried out the initial characterization of trangenic mice with prostatic specific expression of FGFR-4 Arg388 and Gly388 constructed a FGFR-4 siRNA lentivirus and a PC3 siRNA cell line and identified Ehm2 as an FGFR-4 Arg388 regulated gene and characterized its role in prostate cancer. These key reagents will allow us to evaluate the effects of FGFR-4 on prostate cancer progression in vivo. Further studies of FGFR-4 Arg388 regulated gene expression in prostate cancer tissues are underway.
- Anatomy and Physiology
- Medicine and Medical Research