Accession Number:

ADA446435

Title:

Antibody-NKG2D Ligand (Rae-1Beta) Fusion Protein for Breast Cancer Therapy

Descriptive Note:

Final rept. 1 Aug 2004-31 Jul 2005

Corporate Author:

MIAMI UNIV FL

Personal Author(s):

Report Date:

2005-08-01

Pagination or Media Count:

17.0

Abstract:

Antibody-NKG2D ligand fusion protein targeted against the breast tumor antigen HER2. Using murine breast tumors designed to express the HER2 target antigen and the murine NKG2D ligand Rae-1BETA, we constructed an anti-HER2 IgG3-CH3-Rae-1BETA fusion protein by genetically fusing Rae-1BETA at the 3 end of CH3 domain of anti-HER2 IgG3 antibody. The purified Rae-I fusion proteins demonstrated ability to bind antigen on tumor cells and NKG2D on NK cells. The antibody-Rae-1 fusion proteins showed increased cytotoxic activity directed against tumor targets.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE