Zebrafish Models of BCR-ABL-Induced Leukemogenesis
Final rept. 20 Sep 2004-19 Sep 2005
DANA-FARBER CANCER INST BOSTON MA
Pagination or Media Count:
We plan to study the consequences of BCR-ABL expression in myeloid cells, using the zebrafish model system. The fundamental genetic mechanisms that control hematopoiesis are well conserved, and many of the genes known to regulate these processes in mammals have been recently identified in zebrafish. Advantages of the zebrafish provide an unparalleled opportunity to identify specific genes whose mutational inactivation blocks BCR-ABL activity, and whose products therefore serve as potential targets for the development of small molecule inhibitors that could be used in treatment of CML. Determination of the patho-physiologic significance of BCR-ABL in transgenic zebrafish models and stable transgenic zebrafish models for BCR-ABL induced leukemia will establish the necessary groundwork that will be valuable in conducting future modifier screens.
- Anatomy and Physiology