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Prostate Dose Escalation by Innovative Inverse Planning-Driven IMRT

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Annual rept. 1 Nov 2004-31 Oct 2005

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With the development of computer controlled MLC, IMRT now provides unprecedented means to deliver 3D-dose distributions with sub-centimeter resolution. Inverse planning is at the foundation of IMRT and critically determines its success. As practiced now, however, the capacity of IMRT is greatly underutilized because of the inferior performance of the inverse planning systems. Because of the tacit ignorance of intra-structural tradeoff, the IMRT plans generated by these systems for prostate treatment are, at best, sub-optimal and our endeavor of providing the best possible patient care is compromised. We have carried out a systematic study on this unexplored issue and developed innovative techniques to improve prostate IMRT. A number of important milestones have been accomplished, which include i established a theoretical infrastructure of spatially non-uniform penalty scheme for inverse planning ii developed method for incorporating existing clinical knowledge into inverse planning iii proposed an electron density mapping technique to improve the quality of cone-beam CT CBCT images iv established a robust technique for using onboard CBCT for on-treatment IMRT dose validation v improved prostate IMRT beam orientation selection by integrating organ specific EUD. It is expected these tools will greatly facilitate the imaging, planning, delivery and quality assurance of prostate IMRT.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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