Accession Number:

ADA446393

Title:

Test for Sensitive Detection and Accurate Assignment of TP53 Variants in Tumor DNA

Descriptive Note:

Final rept. 1 Sep 2004-31 Aug 2005

Corporate Author:

SPECTRAGENETICS LLC PITTSBURGH PA

Personal Author(s):

Report Date:

2005-09-01

Pagination or Media Count:

16.0

Abstract:

Accurate, sensitive assessment of the mutational status of tumors enables genotypephenotype studies and increases the understanding of tumor etiology, progression, recurrence and response to therapy. Preliminary Peptide Mass Signature Genotyping PMSG results using bacterial cultures indicated tremendous potential and proof of concept experiments demonstrated that the PMSG process could be converted to an in vitro test. Expansion of proof of concept protocols will provide a mutation detection process suitable for validation and clinical testing.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE