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The Use of a Cognitive Protectant to Help Maintain Quality of Life and Cognition in Premenopausal Women with Breast Cancer Undergoing Adjuvant Chemotherapy

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Annual summary, 3 Sep 2004-2 Sep 2005

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Significant reductions in quality of life and cognitive function are experienced by women with breast cancer who are receiving adjuvant chemotherapy. These decrements can be identified in some women even several years following treatment. The majority of relevant research has been based on retrospective data in women with breast cancer. Current estimates suggest that 25 of breast cancers will be diagnosed in women under age 50, yet very little data are available regarding younger womens cognitive function and quality of life during chemotherapy. The goal of the proposed study is to examine changes in cognitive function and quality of life in 30 premenopausal women with breast cancer who are receiving chemotherapy. To determine if accelerated menopause is associated with change in cognition and quality of life, serum hormone levels, measures of cognitive function, quality of life variables, and symptoms of depression will be assessed. The participants will undergo measurements of cognition by the Cognitive Difficulties Scale and High Sensitivity Cognitive Screen quality of life will be measured by the MOS-SF-36 and the BCPT Symptom Checklist fatigue will measured by the FACT-An and the Brief Fatigue Inventory Depression and Coping will be measured by the Beck Depression Index and the Brief COPE and Hope, Optimism, and Pessimism will be measured by the Hope scale, the LOT-R, and the PANAS. Measures will be collected at baseline before the initiation of chemotherapy, prior to the third cycle of chemotherapy, and following completion of chemotherapy, but prior to any additional treatment. A better understanding of the association between chemotherapy and quality of life is essential to provide appropriate preventive approaches and interventions aimed at maximizing the quality of life and health of young women diagnosed with breast cancer.

Subject Categories:

  • Psychology
  • Medicine and Medical Research
  • Stress Physiology
  • Pharmacology

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