Accession Number:

ADA446372

Title:

Identification of a Protein for Prostate-Specific Infection

Descriptive Note:

Annual summary 1 Dec 2003-30 Nov 2004

Corporate Author:

CALIFORNIA UNIV LOS ANGELES

Personal Author(s):

Report Date:

2004-12-01

Pagination or Media Count:

5.0

Abstract:

In this proposal, we will identify and clone a protein that can be used to generate infection-specific gene therapy vector. We expect that using this protein to modify various gene therapy vectors, we can specifically deliver cytotoxic genes into prostate cancer cells using systemic treatment, and eventually eradicate metastatic prostate cancer cells in patients. During the first year, we have generated the cDNA expression library Task 1. We have picked up clones to check the percentage of clones that contain cDNA inserts and the sizes of the cDNA inserts. We found that approximately 70 of our clones containing cDNA inserts. Most of the inserts are between 1.0 to 2.0 kb. We have screened approximately 1,200 colonies, fulfill the requirement as our SOW stated and we expected by screening more cDNA clones, we will be able to identify the genes related to tissue-specific delivery of lentiviral genes into prostate cells.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE