Accession Number:

ADA446369

Title:

A New Marker for Tamoxifen Resistance in ER-Dependent Breast Cancer

Descriptive Note:

Final rept. 1 Sep 2003-31 Aug 2005

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Personal Author(s):

Report Date:

2005-09-01

Pagination or Media Count:

20.0

Abstract:

While the significance of the protein kinase AKT expression lactivity in human breast cancer has become increasingly evident, consistent alterations of a specific isoform have not been well documented, A specific isoform of AKT may be preferentially activated or activated proteins may have different substrate preferences, providing a therapeutic opportunity to target a particular isoform. Previously, we have demonstrated a cross-talk between the growth factor and estrogen transduction pathways, converging in the ErbB2PI 3-KAKT1 signaling.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE