A New Marker for Tamoxifen Resistance in ER-Dependent Breast Cancer
Final rept. 1 Sep 2003-31 Aug 2005
GEORGETOWN UNIV WASHINGTON DC
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While the significance of the protein kinase AKT expression lactivity in human breast cancer has become increasingly evident, consistent alterations of a specific isoform have not been well documented, A specific isoform of AKT may be preferentially activated or activated proteins may have different substrate preferences, providing a therapeutic opportunity to target a particular isoform. Previously, we have demonstrated a cross-talk between the growth factor and estrogen transduction pathways, converging in the ErbB2PI 3-KAKT1 signaling.
- Medicine and Medical Research