Seamless Integration of Detection and Therapy for Breast Cancer Using Targeted Engineered Nanoparticles
Annual rept. 15 May 2004-14 May 2005
RICE UNIV HOUSTON TX
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This report provides a summary of the progress established by our multidisciplinary, highly synergistic team of researchers from M.D. Anderson Cancer Center and Rice University on their continuous effort of exploring and development of nanoparticle-based methods to breast cancer detection, imaging, and therapy. During the first two years of this project, the team has demonstrated in a series of controlled experiments that the intense local heating induced by infrared illumination of nanoshells can be used to photothermally ablate cancer cells tagged with nanoshells. One of the recent accomplishments of the team was the development of a novel nanoshell- based all-optical platform technology for integrating cancer imaging and therapy. Nanoshells, designed to both absorb and scatter in the NIR spectral region, were conjugated with anti-HER2 antibody to specifically bind to SKBr3 breast cancer cells. Upon binding to the cells, nanoshells targeted against HER2 were seen to provide a significant increase in the scatter-based optical contrast. The anti- HEIU-labeled nanoshells alone were seen to be nontoxic to the cancer cells. However, after irradiation with NIR light, the conjugated nanoshells were seen to mediate photothermal effects that resulted in the death of cancer cells. These studies indicate that immunotargeted nanoshells can provide, in a single nanoshell, scattering contrast for imaging cancer cells with high sensitivity, while also exhibiting sufficient absorption to enable effective photothermal therapy of the cancer cells.
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