Unique Proteins Expressed by Blood Vessels in Skeletal Sites Colonized by Breast Cancer Cells
Annual rept. 1 Aug 2004-31 Jul 2005
PENNSYLVANIA STATE UNIV UNIVERSITY PARK
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This study focuses on the identifying differences in the vasculature in the ends of long bones where breast cancer cells tend to lodge, as compared to the vasculature of the central marrow cavity. We have found differences in RNA expression by microarray analysis. The bone-derived vasculature expresses five RNA messages in greater abundance 2-fold or more than the marrow-derived vasculation. Most of the more abundant RNA is related to angiogenesis. We have also found that the bone-derived cells express more surface protein e-selectin that can tether breast cancer cells. The expression of e-selectin is enhanced by secretions from early stage osteoblasts. This finding may help explain why breast cancer cells preferentially lodge in regions of bone where osteoblasts are abundantly present.
- Anatomy and Physiology
- Medicine and Medical Research