Changes in Ovarian Stromal Function in Premenopausal Women Undergoing Chemotherapy for Breast Cancer
Annual summary rept. 1 Aug 2004-31 Jul 2005
MAYO CLINIC ROCHESTER MN
Pagination or Media Count:
The objective of this pilot study is to look for evidence of whether androgen levels are adversely affected by adjuvant chemotherapy for breast cancer and whether low androgen levels are correlated with the frequency and severity of fatigue, weight gain, psychological symptoms, vasomotor symptoms and libido. This pilot trial will use a longitudinal, descriptive design and will measure both subjective and objective measures of menopausal related phenomena in 20 premenopausal women receiving chemotherapy. Data collection will include blood draws and questionnaire completion at 4 time periods baseline before treatment, mid-treatment, immediate post-treatment and 6 months later. Questionnaires will include the Female Sexual Function Index, Greene Climacteric Scale, Profile of Mood States, cognitive and physical subscales of the Schwartz Fatigue Scale and a menses diary. Data analysis will involve descriptive statistics and plots of the hormone levels over time as well t-tests to examine changes in hormone levels. Correlational analysis will be done to look at the relationship of symptoms to various hormone levels. Final HSPRB and IRB approval received 405, recruitment began 61OS. If a connection between low levels of androgens and symptoms is found, androgen replacement may be a viable treatment option for breast cancer survivors.
- Medicine and Medical Research