The Role of Calgranulin Overexpression in Breast Cancer Progression
Final rept. 15 Aug 2003-14 Aug 2005
CASE WESTERN RESERVE UNIV CLEVELAND OH
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The mechanism responsible for the progression of breast cancer to estrogen independence is currently unknown. We have demonstrated a strong correlation between elevated expression of Calgranulin A and Caigranulin B and the loss of estrogen dependence. Experiments using estrogens and antiestrogens have demonstrated that this is not the result of a direct interference with estrogen receptor signaling and must therefore require additional steps. Interestingly, we have also shown that expression of calgranulins in estrogen independent breast cancer cells is quite variable and may be differentially regulated during the cell cycle. Regulation of calgranulin expression by the cytokine Oncostatin M highlights a potential link between the cytokine and estrogen receptor signaling pathways. 15.
- Medicine and Medical Research