Accession Number:

ADA446266

Title:

In Vitro Toxicity of Aluminum Nanoparticles in Rat Alveolar Macrophages

Descriptive Note:

Master's thesis

Corporate Author:

AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING AND MANAGEMENT

Personal Author(s):

Report Date:

2006-03-01

Pagination or Media Count:

111.0

Abstract:

The purpose of this research is to characterize the in vitro cellular effects of rat lung macrophages to exposure to aluminum oxide nanoparticles Al2O3-NP 30 and 40nm compared to aluminum nanoparticles Al-NP 50, 80, and 120nm. This study concentrates on cell viability, mitochondrial function, phagocytosis ability, and cytokine response. Results indicate no to minimal toxicological effects on macrophages exposed as high as 500 956gml for 24 hours with Al2O3-NP. However, there was a significant delayed toxicity that occurred at 96 and 144 h post exposure. Al-NP shows sight to moderate toxicity after 24 h exposure at 100 and 250 956gml. The phagocytic ability of these cells was significantly hindered by exposure to each size of the Al-NP at 25 956gml for 24 hours, but not by the Al2O3-NP. A series of cytokine and nitric oxide assays performed show none of these aluminum nanoparticles are inducing an inflammatory response.

Subject Categories:

  • Anatomy and Physiology
  • Toxicology
  • Inorganic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE