Vitamin D-Prostaglandin Interactions and Effects on Prostate Cancer
Annual summary rept. 15 Sep 2004-15 Sep 2005
LELAND STANFORD JUNIOR UNIV STANFORD CA
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Prostate cancer PCa is the most commonly diagnosed malignancy and the second leading cause of cancer death in North American men 1. According to the American Cancer Society more than 232,000 men will be diagnosed with PCa in 2005 and approximately 10 of these men will die of the disease 1. Primary therapy for PCa involves the removal of the prostate by surgery or radiation therapy. Unfortunately, after initial treatment PCa often recurs. Androgens regulate normal prostate development and growth. Surgical or medical androgen deprivation has been used as the standard treatment for PCa that fails primary therapy 2, 3. Although there is a good initial response to androgen ablation in most men, tumors will progress to androgen independence resulting in death 4 since there is currently no adequate treatment for this advanced disease. Our current investigation is aimed at the development of new therapies to treat PCa. la,25- Dihydroxyvitamin D3 calcitriol, the hormonally active form of vitamin D, is a promising new therapeutic agent for PCa therapy 5-15.
- Medicine and Medical Research