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Integrated Cancer Research in Five Thematic Areas in Interest

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Annual rept. 1 Jul 2004-30 Jun 2005

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During the last FY of the award, the Cancer Institute of Long Island benefited from CPMRP funding in a manner consistent with the proposed activities of the award. In the area of core instrumentation acquisition, a Carl Zeiss Total Internal Reflection Fluorescence TIRF microscope has been ordered. This technology is vital to bridge the gap in CDMRP funded optics systems at Stony Brook, by providing cancer researchers with the capability to study localization at the cell membrane level. A new, state-of-the-art imaging system was requested via programmatic modification that was submitted and approved by CDMRP under separate cover a Carl Zeiss Fluorescence Correlation Spectroscopy FCS Confocal Microscope, is operational and is being utilized to measure events at the single molecule level. The university has organized funds to construct a dedicated ISO Class 7 clean room to support the FCS Confocal Microscope. Consistent with the funding for this initiative were the granting of multi-year RSU packages, or Research Support Units. RSUs are a mechanism to ensure necessary support for junior faculty and work as enhancements to enable the successful establishment of their laboratories. Each RSU provided support for laboratory personnel, small or specialized research equipment, and supplies. During the last funding year three individuals were recruited into this initiative. The faculty designees for this activity are Howard Adler, MD, Assistant Professor of Urology on-going RSU, Howard Crawford, PhD, Assistant Professor of Pharmacological Sciences on-going RSU, Marjana Maletic-Savatic, MD-PhD, Assistant Professor of Neurology new RSU. Dr. Adler is investigating the angiogenesis of prostate cancer from a translational approach. Dr. Crawford continues to make significant strides in understanding cell and protein signaling events in pancreatic and breast cancer. Dr. Maletic-Savtic is investigating the proliferation of brain carcinoma and demyelinating of neurons due

Subject Categories:

  • Medicine and Medical Research

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