Dietary Fish Oil in Reducing Bone Metastasis of Breast Cancer
Annual rept. 1 Sep 2004-31 Aug 2005
TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON
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We hypothesized that fish oil will be inhibitory for bone metastasis of breast cancer cells. For the successful formulation of a novel therapeutic supplement using fish oil diet, the molecular mechanism of fish oil action needs to be determined. We report three novel findings in our annual report for this proposal towards the mechanism of action of fish oil fish oil or pi-3 polyunsaturated fatty acids PUFAs 1 increase the level of tumor suppressor protein PTEN, 2 inhibit the activity of PI 3 kinase, thus blocking a potent growth promoting signaling pathway and 3 increase gene expression of BMP-2. We are currently investigating each of these observations in details to further elucidate the underlying mechanism of fish oil induced breast cancer growth inhibition. The role of BMP-2 in skeletal metastasis of breast cancer cells is not known. We are also currently studying the effect of BMP-2 overexpression on breast tumor metastasis to bone using a well established nude mouse model for bone metastasis using cardiac injection. The same approach is also being used to study the effect of fish oil diet on bone metastasis.
- Anatomy and Physiology
- Food, Food Service and Nutrition