Accession Number:

ADA445848

Title:

Mean Arterial Pressure and Cerebral Blood Flow Regression for Prediction of Central Nervous System Oxygen Toxicity

Descriptive Note:

Corporate Author:

NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD

Report Date:

2004-09-01

Pagination or Media Count:

21.0

Abstract:

One toxic effect of hyperbaric oxygen HBO exposure is tonic-clonic seizures. To assess the association between seizure onset, mean arterial pressure MAP and cerebral blood flow CBF, male Yorkshire swine were chronically instrumented to measure those parameters during exposure to 3, 4, 5 or 6 atmosphere absolute ATA on 100 oxygen. Seizure latency differed significantly as a function of pressure P 0.05. The increase in MAP and CBF correlated with seizure latency and multiple regression analysis demonstrated that MAP and CBF jointly predict seizure latency. These results demonstrate that a measurable increase in MAP and CBF may be a useful predictive tool, which may improve the safety of diving operations and clinical treatments requiring HBO. seizure,

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE