Melatonin Does Not Provide Protection Against Hyperbaric Oxygen (HBO) Induced Seizures
Technical rept., 1999-2001
NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD
Pagination or Media Count:
Acute exposure to hyperbaric oxygen HBO can result in toxicity to the central nervous system CNS. The most onerous manifestation of CNS oxygen toxicity is the onset of generalized tonic-clonic seizures. HBO-induced convulsions are of particular importance to the Navy, as it is a limiting factor in the duration of diving missions involving surface supplied oxygen and use of the LAR V and MK-1516 closed-circuit SCUBA apparatus, and the application of HBO medical treatment for decompression sickness. The causal mechanism of HBO-induced seizures is presently unknown. Melatonin has not been tested in its capacity as an anti-convulsant in HBO conditions likely to produce seizures 6 atmospheres absolute. The goal of this research was to examine melatonin prophylaxis in HBO conditions that reliably produce CNS toxicity.
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