Accession Number:

ADA445067

Title:

Complement Inhibitor APT070 Dramatically Reduces the Need for Resuscitation and Improves Survival in Controlled Isobaric Rat Hemorrhage Model

Descriptive Note:

Conference paper

Corporate Author:

VACCINE AND IMMUNOLOGY RESEARCH INST WASHINGTON DC

Personal Author(s):

• Baranyi, Lajos
• Szebeni, Janos
• Bentley, Timothy B.
• Esser, Dirk
• Smith, Richard
• Purger, David
• Alving, Carl R.

Report Date:

2004-09-01

Pagination or Media Count:

9.0

Abstract:

The complement system C becomes activated during hemorrhagic shock in a rat isobaric hemorrhage model, a process significantly aggravating the outcome of shock. Consequently, inhibition of C activation may have beneficial effects on both survival and metabolic status of animals subjected to shock.

Descriptors:

• *RATS
• *SURVIVAL(PERSONNEL)
• *ISOBARS(PRESSURE)
• *HEMORRHAGIC SHOCK
• ACTIVATION
• METABOLISM
• ANTIGENS
• RESUSCITATION
• ANAPHYLATOXINS
• SERINE
• PEPTIDE HYDROLASES
• ANATOMICAL MODELS
• TRAUMA
• ANTIBODIES
• ANIMALS
• INHIBITION

Subject Categories:

• Medicine and Medical Research
• Escape, Rescue and Survival
• Meteorology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE