Accession Number:

ADA445067

Title:

Complement Inhibitor APT070 Dramatically Reduces the Need for Resuscitation and Improves Survival in Controlled Isobaric Rat Hemorrhage Model

Descriptive Note:

Conference paper

Corporate Author:

VACCINE AND IMMUNOLOGY RESEARCH INST WASHINGTON DC

Report Date:

2004-09-01

Pagination or Media Count:

9.0

Abstract:

The complement system C becomes activated during hemorrhagic shock in a rat isobaric hemorrhage model, a process significantly aggravating the outcome of shock. Consequently, inhibition of C activation may have beneficial effects on both survival and metabolic status of animals subjected to shock.

Subject Categories:

  • Medicine and Medical Research
  • Escape, Rescue and Survival
  • Meteorology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE