Preclinical Mouse Models of Neurofibromatosis
Final rept. 1 Oct 2002-31 Oct 2005
CALIFORNIA UNIV SAN FRANCISCO
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This report describes three years of research by a Consortium of investigators who worked to develop, characterize, and utilize strains of mice that accurately model tumors found in persons with NF1 and NF2. This Consortium has generated novel models of NF1 and NF2-associated tumors and has exploited these strains to investigate biologic and preclinical questions. The Consortium also organized scientific conferences on the pathologic classification of murine NF-associated neural tumors and on the use of mouse models of NF-associated tumors to test new therapies, and published the proceedings of the pathologic classification conference. The novel strains that have been developed have been shared widely with the research community. The investigators have collaborated closely with each other and have shared expertise and reagents extensively. This NF Consortium is a member of the Moue Models of Human Cancer Consortium of the National Cancer Institute and is participating fully in the activities of the group. A new award from the CDMRP for Neurofibromatosis that received a high priority score will support the continuing efforts of this research group from 2005- 2008.
- Anatomy and Physiology
- Medicine and Medical Research