PTEN Regulates Beta-Catenin in Androgen Signaling: Implication in Prostate Cancer Progression
Annual rept. 1 Mar 2004-28 Feb 2005
STANFORD UNIV CA
Pagination or Media Count:
The androgen-signaling pathway is important in the growth and progression of prostate cancer. The growth promoting effects of androgen are mediated mostly through the androgen receptor AR. P13KAkt plays a critical role in prostate cancer cell growth and survival. It has been shown that the effect of PI3KAkt in prostate cells is mediated through androgen signaling. The PI3K inhibitor, LY294002, and a tumor suppressor, PTEN, negatively regulate the P13KAkt pathway and repress AR activity. However, the molecular mechanisms whereby P13KAkt and PTEN regulate the androgen pathway are currently unclear. The proposed studies examine whether beta-catenin is a major downstream effector of the P13KAkt and PTEN pathways in androgen-mediated prostate cell growth. Several sets of in vivo and in vitro experiments have been performed to further test our hypothesis during this funding year. Successful completion of the proposed studies should provide fresh insight into the novel link between the PI3K, Wnt, and androgen pathways, which may help us to identify new pathways that can be targeted for prostate cancer treatment.
- Anatomy and Physiology